Rapid risk assessment released on CRE in Italy

11 June 2019

Article: 53/2303

The European Centre for Disease Prevention and Control (ECDC) has released a rapid risk assessment on a large outbreak of New Delhi metallo-beta-lactamase (NDM)-producing, carbapenem-resistant Enterobacteriaceae (CRE), from the Tuscany region in Italy.

Between November 2018 and May 2019, seven Tuscan hospitals notified a total of 350 cases. Due to its size, and the resulting change in the epidemiology of CRE, the reported outbreak is considered a significant event. The change in the type of carbapenemase further reduces treatment options because NDM-producing CRE are not susceptible to some of the new beta-lactam/beta-lactamase inhibitor combinations.

Reported outbreaks and examples of cross-border transmission of NDM-producing CRE in EU/EEA countries demonstrate the transmission potential of NDM-producing CRE in European healthcare systems. Outbreaks, such as the one in Tuscany, present a risk for cross-border transmission and further spread to other EU/EEA countries, especially if the affected area is a major tourist destination.

Source: ECDC, 4 June 2019